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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12—particularly from supplements or injections—may be associated with certain health concerns, though these are correlations rather than proven causal relationships

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For girls and women confronting gonadotoxic chemotherapy, peptides that decrease oxidative damage or enhance local growth factor signaling may be administered prior to, during, or after chemo to protect against follicle loss